The RFID (Radio Frequency IDentification) technology is a well-known wireless application for traceability, logistics, and access control. It became ubiquitous in industry and our daily life (ticketing, payment, passports, car keys, etc.). RFID is nowadays a standardized technology; its inherent advantages, which are unitary, identification, wireless communication, and low cost of tags, provide it with decisive practical benefits that drive new developments in terms of concepts and applications. This trend is largely confirmed by the market forecast, but also by its implementation in the area of health (smart hospital), assistance to persons, anti-counterfeiting, as well as by its perspective in terms of new paradigms for distributed ambient intelligence and the Internet of Things. The first part of this paper briefly reviews the fundamental concepts of the RFID technology, and shows its link with the radio science. A state of the art including the presentation of current performance and developments is also summarized. The second part illustrates the impact of RFID to the service of our society with a focus of applications in the field of autonomy and handicap. Finally, the last part highlights a panorama of perspectives and the future directions of RFID applications dedicated to the service of Humanity.